Gut Connect 365 Review: Pros, Cons, Effectiveness, and Safety

Gut Connect 365 Review: Pros, Cons, Effectiveness, and Safety


  • 60 day money back guarantee
  • although limited, some ingredients have some benefits for gut health
  • all orders include free shipping


Reading: How to drink gut connect 365

  • no evidence to support that this exact mix of ingredients promotes gut health
  • high price
  • contains aloe vera, which can be toxic

what is gut connect 365?

gut connect 365 is a supplement manufactured by united naturals.

at the head of united naturals is dr. Vincent Pedre, M.D, a physician who believes that the combination of Eastern and Western medicine should be used to address the needs of patients.

dr. vincent pedre is the medical director of pedre integrative health and the president of dr. wellness stone.

dr. pedre seems to be in a unique position to provide insight into this gut health supplement. His approach to medicine involves a holistic understanding of preventive health, integrative and functional medicine, and general wellness.

While there is a lot of talk about the connection between gut health and overall wellness, as a healthcare professional, I think it’s important to bring solid research to this conversation.

can gust connect 365 really support a healthy intestinal lining, improve digestion and fight bloating? Let’s dive into the heart of the matter: the ingredients.

ingredient evaluation

There are many ingredients in Gut Connect 365 that can improve the strength and integrity of the gut. below, we take a closer look at each:

l-glutamine (5,000mg)

l-glutamine is an amino acid that is a source of fuel for the cells lining the intestines.

By feeding these important cells, glutamine can help increase the integrity of the intestines, which prevents harmful bacteria from entering.

l-glutamine is an important nutrient that also helps rebuild and repair the intestinal walls.

Supplemental l-glutamine has skyrocketed in popularity in recent years. this may be due to the variety of health claims that support its use.

There have been a few randomized clinical trials (the gold standard of research) showing that glutamine supplementation can benefit the digestive system. (1)

a 2017 animal study shows that there is some evidence to support that l-glutamine supplementation may help relieve constipation and improve bowel function. (2)

However, there are very few studies that conclude that glutamine can help relieve other gastrointestinal symptoms.

Glutamine deficiency is very rare. When the body is under severe stress, such as in critical illness, it may not be able to produce enough glutamine. in this rare case, supplementation may be beneficial.

In most other scenarios, without further research, l-glutamine supplementation and its benefits for gut health are not supported by enough solid research.

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More research should be done before recommending glutamine supplementation to people looking to improve their gut health.

quercetin dihydrate (500mg)

Quercetin dihydrate is a compound found in many fruits, vegetables, seeds, and nuts.

It is rich in antioxidants, making it attractive to people looking to slow the aging process and reduce the risk of chronic disease.

Unfortunately, on its own, quercetin dihydrate has low bioavailability, meaning it is not well absorbed by the body. (3)

Furthermore, this compound also lacks research on how it can support gut health.

striped elm bark (150 mg)

Slippery elm bark has been used as an herbal remedy to treat wounds and a host of gastrointestinal problems for hundreds of years.

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When mixed with water, slippery elm bark turns gelatinous. this gel can coat the lining of the gastrointestinal tract and can help soothe the mouth, throat, stomach, and intestines.

While there has been little scientific research on slippery elm bark, there have been a few studies showing promising results.

It is important to note that these studies only address people with specific gastrointestinal disorders, such as irritable bowel syndrome (IBS). (4)

Studies also include a mixture of other compounds such as licorice root, lactulose, and oat bran. (5)

Organic Marshmallow Root (150mg)

You may be wondering how an ingredient in your favorite campfire treat has any health benefits. bagged marshmallow is no longer made with marshmallow root.

however, marshmallow root is an herb that has been used for thousands of years to treat a variety of ailments, including digestive, skin, and respiratory conditions.

Most of the research related to marshmallow root has been conducted on animals. scientists have yet to investigate marshmallow root in humans. (6)

therefore, more studies would be needed to confirm if this supplement is beneficial for people.

n-acetyl glucosamine (150mg)

n-Acetyl glucosamine is chemically similar to glucosamine and may help reduce joint pain and stiffness and may help protect the lining of the stomach and intestines.

A 2018 study found that n-acetylglucosamine may help reduce the severity and recurrence of inflammatory bowel disease (IBD). (7)

another study found that n-acetylglucosamine may help relieve symptoms of ibd, including nausea, diarrhea, and abdominal pain. (8)

licorice root extract (150mg)

Licorice root is derived from the licorice plant and has been used as an herbal remedy to help treat a variety of conditions, from stomach pain to respiratory symptoms.

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There is evidence showing that an extract containing glabridin and glabrene, which are compounds found in licorice root, was effective in relieving an upset stomach. (9)

however, high-quality research to support its use to improve gut health is lacking.

aloe vera extract (50mg)

Aloe vera extract is often used in gel form to treat burns and other wounds. it also acts as a mild laxative in the body.

research that aloe vera supports gut health has been limited to studies whose participants have ibs. (10)

Also, aloe vera has been criticized as a potential carcinogen.

A 2016 study found that taking aloe vera can cause diarrhea, lower potassium levels and, in rare cases, lead to kidney failure. (11)

According to this research, aloe vera extract also showed clear evidence of carcinogenic activity in rats. It was classified by the International Agency for Research on Cancer as a possible human carcinogen.

maitake mushroom (30mg)

Mushrooms, in general, act as prebiotics and can help stimulate the growth of beneficial bacteria in the gut.

There is insufficient evidence to support that maitake mushrooms have benefits for gut health beyond those of any other type of mushroom.

zinc orotate (20mg)

Zinc orotate is a form of zinc that binds to orotic acid. There is some evidence to suggest that zinc supplementation may help with symptoms related to gastrointestinal illness. (12)

More research is needed to understand whether zinc supplementation can improve gut health in healthy people.

side effects, safety and dosage

The starting dose of gut connect 365 is 1 scoop in 8 oz. of water per day. an 8.4-ounce bottle should last about a month.

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According to research, glutamine, the main ingredient in this product, does not appear to pose a health risk or cause any unwanted side effects. (13)

However, this product contains aloe vera, which raises some potential safety issues. According to research, taking aloe vera orally can be toxic and have carcinogenic effects. (11)

the product contains ingredients derived from shellfish, so allergy sufferers should avoid it.

In addition, people with sensitivity to msg (monosodium glutamate) may also be sensitive to this product.

Before taking this product, or any dietary supplement, you should consult with your healthcare provider to ensure its safety for you.

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cost and where to buy

gut connect 365 is $54 for an 8.4 oz can. when you buy 3 or 6 bottles, you will receive a discount.

  • 1 pot: $54
  • 3 pots: $134 ($44.66 each)
  • 6 pots: $244 ($40.66 each)

The best place to buy this product is directly from united naturals.

the website indicates that you can request a refund if you are not completely satisfied with the product.

comparison with alternatives

a product with a nutritional profile similar to gut connect 365 is terra origin healthy digestive support.

Like gut connect 365, terra origin gut healthy contains glutamine as a primary ingredient, but it’s in powder form, which can be easily mixed with water.

Terra Origin Healthy Gut can be purchased through Amazon for $23.98 for a one month supply.

many other supplements used to improve gut health contain prebiotics and probiotics.

There has been a lot of solid research suggesting that prebiotics and probiotics can improve gut health and, in turn, overall well-being. (14)

united naturals has a different product with similar gut health benefits called synbiotic 365: advanced probiotic formula.

synbiotic 365 is a digestive health supplement that contains prebiotics, probiotics and a blend of B vitamins.

For those with gastrointestinal issues, the 15 probiotic strains and blend of B vitamins may help reduce GI symptoms.

Research shows that B vitamins play an important role in increasing the number of beneficial bacteria in the gut while suppressing the growth of harmful bacteria. (15)

While gut connect 365 has many ingredients that may improve gut health, the combination of these specific ingredients has not yet been studied.

many supplements claim to improve gut health; however, the optimal combination of ingredients is not yet supported by solid research.

the end result

Can taking gut connect 365 support a healthy intestinal lining, improve digestion and combat bloating? maybe.

The good news is that Gut Connect 365 contains some ingredients that may have some degree of benefit to gut health. although there are few, these ingredients are supported by limited evidence-based research.

The bad news is that many of the ingredients are not backed by solid research and there is no evidence to say that this specific blend will support gut health.

In addition, there appear to be some health risks when taking aloe vera extract.

Also, a month’s product will cost between $40 and $54. this is a high price for a supplement.

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